MEDPAGE TODAY reported: Brain bleed risk more than doubled in infants who missed routine vitamin K shots.
Key Takeaways
- The share of newborns who missed routine vitamin K shots rose to 6.8% in 2025.
- Infants who didn't receive vitamin K shots faced a 47% higher bleeding risk in their first 6 months of life.
- Newborns without vitamin K shots also had doubled intracranial hemorrhage and bleeding-related death risks.
Newborns who missed routine vitamin K shots had higher bleeding risks and more than double the risk of intracranial hemorrhage, a nationwide study of over 5 million infants showed.
Infants who did not receive prophylactic vitamin K shots, the share of which increased from 3.1% in 2017 to 6.8% in 2025, had a 47% higher bleeding risk by 6 months (288.0 vs 185.9 per 10,000; adjusted risk ratio [RR] 1.47, 95% CI 1.43-1.51), reported Heather Burris, MD, MPH, of the Children's Hospital of Philadelphia, and colleagues in JAMA.
They also had more than twice the risks of intracranial bleeding (33.0 vs 13.2 per 10,000; adjusted RR 2.43, 95% CI 2.26-2.62) and death with concurrent bleeding during the birth hospitalization (2.9 vs 1.1 per 10,000; adjusted RR 2.69, 95% CI 2.09-3.47).
Diagnosed vitamin K deficiency tripled in infants and vitamin K deficiency bleeding more than quadrupled during this period, noted Elizabeth Wolf, MD, MPH, of Virginia Commonwealth University in Richmond, and co-authors in a related JAMA Pediatrics research letter.
More>
###