Young and middle-age adults who had at least one dose of a COVID-19 mRNA vaccine were less likely to die of any cause in the following 4 years compared with those who weren't vaccinated, a nationwide French cohort study found. {MEDPAGE Today]

Among over 28 million adults under 60 years of age, the incidence of all-cause mortality among those who received a first dose of mRNA vaccine from May 1 to Oct. 31, 2021, was 0.4% after a median follow-up of 45 months, compared with 0.6% in those who were unvaccinated by Nov. 1, 2021.

Key Takeaways

• In a French cohort, the incidence of all-cause mortality among those who received a first dose of an mRNA COVID vaccine was 0.4% after a median follow-up of 45 months, compared with 0.6% of those who were unvaccinated.
• After standardizing characteristics between the two groups, all-cause mortality incidence was 25% lower in those who had received a COVID shot.
• Vaccinated people were 74% less likely to die in a hospital because of COVID-19 compared with those who weren't vaccinated.

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