Obesity was tied with 16 common health concerns in a longitudinal cohort study, with the magnitude of risk correlating with the level of obesity. [MedPage Today]

Based on the electronic health records of 270,657 participants from the All of Us research program, class III obesity, or a body mass index (BMI) ≥40, had significant associations with the following conditions over a median 3-year follow-up:

• Obstructive sleep apnea (OSA): adjusted HR (aHR) 10.94
• Type 2 diabetes: aHR 7.74
• Metabolic dysfunction-associated steatotic liver disease (MASLD): aHR 6.72
• Gout: aHR 5.63
• Heart failure (HF): aHR 3.49
• Hypertension: aHR 2.92
• Biliary calculus: aHR 2.91
• Atrial fibrillation (AF): aHR 2.77
• Chronic kidney disease: aHR 2.54
• Pulmonary embolism (PE): aHR 2.48
• Deep vein thrombosis (DVT): aHR 2.18
• Hyperlipidemia/dyslipidemia: aHR 2.45
• Gastroesophageal reflux disease: aHR 2.15
• Asthma: aHR 2.14
• Osteoarthritis: aHR 2.06
• Atherosclerotic cardiovascular disease (ASCVD): aHR 1.96

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