A small study identified potential immunologic patterns associated with post-vaccination syndrome, a very rare condition with neurologic symptoms that occurs in some people following a COVID-19 vaccine. [MEDPAGE Today]

Immune cell populations of people with post-vaccination syndrome had lower levels of effector CD4 T cells and higher levels of CD8 T cells that secrete tumor necrosis factor (TNF) compared with healthy controls, reported Akiko Iwasaki, PhD, of Yale University School of Medicine in New Haven, Connecticut, and co-authors in a preprint posted on medRxiv. The paper has not been peer-reviewed.

Post-vaccination syndrome patients had lower levels of antibodies against the SARS-CoV-2 spike protein versus healthy controls, likely because they stopped getting more vaccine doses, the researchers said. Evidence of recent Epstein-Barr virus (EBV) reactivation was seen more frequently in people with post-vaccination syndrome than in vaccinated people without the condition.

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