People with moderately to severely compromised immune systems are especially vulnerable to COVID-19 and may not build the same level of immunity to 2-dose vaccine series compared to people who are not immunocompromised. CDC recommends that people with moderately to severely compromised immune systems receive an additional dose of mRNA COVID-19 vaccine at least 28 days after a second dose of Pfizer-BioNTech COVID-19 or Moderna COVID-19 vaccine. This additional dose is intended to improve the response of people who are immunocompromised to their initial vaccine series.

Although CDC does not recommend additional doses or booster shots for any other population at this time, HHS has announced a plan to begin offering COVID-19 vaccine booster shots this fall. 

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